12/04/2021

Master thesis project – Mode of action of novel antibacterial compounds


  • OFFER DEADLINE
    30/07/2021 13:00 - Europe/Brussels
  • EU RESEARCH FRAMEWORK PROGRAMME
    Not funded by an EU programme
  • LOCATION
    Sweden, Umeå
  • ORGANISATION/COMPANY
    MIMS (The Laboratory for Molecular Infection Medicine Sweden)
  • DEPARTMENT
    Department of Molecular Biology

Project: The obligate intracellular bacterium Chlamydia trachomatis causes over 100 million sexually transmitted infections per year. These infections can cause adverse pregnancy outcomes and infertility and constitute a risk factor for cervical and ovarian cancers. Broad-spectrum antibiotics are commonly used for treatment, but this facilitates resistance development in bystander pathogens and negatively affects the commensal microbiota. The availability of more specific anti-chlamydial compounds would thus be of great clinical value. To this end, we recently screened a chemically diverse library of 36,785 compounds and identified a small set of highly interesting compounds with potent anti-chlamydial activity. We are currently seeking a student for a master thesis project that will initiate investigation into the mode of action and specificity of these compounds. The project will involve a variety of experimental techniques, including culture of human cells and bacteria, fluorescence-based growth and viability assays, and high-content fluorescence microscopy.

Environment: The Sixt Lab is part of the Laboratory for Molecular Infection Medicine Sweden (MIMS) at Umeå University (located in Umeå, Sweden). MIMS is a part of the Nordic EMBL Partnership for Molecular Medicine and of the Umeå Centre for Microbial Research (UCMR), providing a stimulating, collaborative, and highly international environment with excellent access to modern research facilities. The city Umeå itself combines a rich cultural life with exceptional closeness to nature and is particularly welcoming to internationals.

Qualifications: The ideal candidate must be at the final stage of master level studies in molecular biology, microbiology or an equivalent subject area. Previous lab experience with human cell culture and/or molecular techniques is a strong merit. Candidates are expected to be proficient in written and spoken English.

Application: Interested students are welcome to send an application to barbara.sixt@umu.se. Applications should include (as a single PDF file in English): 1) a letter of motivation describing the applicant’s specific motivation, 2) a curriculum vitae, and 3) a copy of the applicant’s transcript records. Application is possible from now until a suitable candidate was found.

To find out more about the lab and our research, please visit our website: http://www.sixtlab.org

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