Marie Skłodowska-Curie Actions

MSCA-IF on dynamics of mitochondria-associated membranes

    15/08/2020 00:00 - Europe/Athens
    H2020 / Marie Skłodowska-Curie Actions
    Université Claude Bernard Lyon 1
    CarMeN Laboratory
    CarMeN Laboratory, Team 3 « Organelle Communication and Diabetes »

Dr Béatrice Morio (Orcid 0000-0002-2418-1438), from the CarMeN Laboratory at the University of Lyon, welcomes postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Individual Fellowships (MSCA-IF) at this University. Please note that applicants must comply with the Mobility Rule (more information: http://sl.ugr.es/09Qg).

Brief description of the Centre/Research Group

CarMeN laboratory -INSERM U1060 / INRA U1235 / Lyon 1 University / INSA de Lyon 1, http://carmen.univ-lyon1.fr/) is a biomedical research laboratory in the field of cardiovascular diseases, metabolism, diabetes and nutrition. These diseases share common pathophysiological determinants related to the environment, lifestyle and population ageing. The main objective of CarMeN lab is to improve our understanding of these important diseases and to develop new treatments and preventive strategies for a better care of the patients.

CarMeN lab is a center of excellence which gathered the major research forces in these fields in Lyon. Gathering almost 180 persons, including basic scientists and medical practitioners to strengthen the interactions between cognitive research and biomedical and clinical research, and operating state of the art clinical research facilities (CRNH-RA and CIC) and technological platforms (genomics, lipidomics, imaging), CarMeN lab provides an unique environment to conduct translational research. It is certified ISO 9001 since 2008 for the realization of research projects and the teaching and training of students. CarMeN lab contributes to the European Centre for Nutrition and Health (https://www.univ-lyon1.fr/recherche/le-centre-europeen-de-nutrition-pour...).

Brief description of the team

The research team involves basic researchers and clinicians with complementary skills in the field of insulin action and secretion. Our aim is to identify common molecular mechanisms by which glucolipotoxicity-associated metabolic stress affect hepatic/muscle insulin action and pancreatic insulin secretion, thus contributing to the two components of type 2 diabetes (T2DM). In recent years, we focused on the involvement of mitochondria and endoplasmic reticulum (ER) in the functional alterations of these tissues, highlighting for the first time a key role of structural and functional interactions between the two organelles in the alterations of insulin action and secretion in T2DM. Our goal is to clarify the mechanisms by which ER-mitochondria interactions are involved in the pathogenesis of T2DM and whether the control of these interactions could be a new target to improve both insulin action and secretion in T2DM.

The research team has access to facilities (cytometry, histology, microscopy, genomics, proteomics, lipidomics, in vivo exploration, clinical research centres) which allow building intergrative researches, from cell biology, to preclinical studies involving nutritional and transgenic models, and clinical trials in healthy individuals and patients.

Project description

The liver is a major organ that coordinates host adaptations to gut-derived nutrients. Mitochondria and ER tightly regulate liver nutrient sensing and metabolic adaptations, shaping its metabolic flexibility. Both organelles interact through contact points (named MAMs) in order to exchange calcium and lipids, and MAM integrity settles metabolic flexibility of the liver. Disrupted MAM integrity in obesity is linked to liver steatosis and insulin resistance. The laboratory has identified amino acids able to influence the integrity and function of MAMs in the liver. The overall goal of the project is to decipher the molecular mechanisms by which these amino acids influence the integrity and function of MAM, and to elucidate the association with alteration in hepatic metabolism.

For a correct evaluation of your candidature, please send the documents below to Dr Béatrice Morio : beatrice.morio@inrae.fr



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